反应详情

N-(4-Bromo-3-methyl-5-isoxazolyl)-8-quinolinesulfonamide was prepared, in the same manner as described in Example 96, from 5-amino-4-bromo-3-methylisoxazole and 8-quinolinesulfonyl chloride in 62% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 169°-171° C.

1. customPurification
2. customwas achieved by recrystallization from ethyl acetate/hexanes
3. customto give a crystalline solid, m.p. 169°-171° C.