8-Quinolinesulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-8-quinolinesulfonamide

HRID 1899684Notes

Reaction equation

HRID 1899684 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[S:19](Cl)(=[O:21])=[O:20])[CH:12]=[CH:11][CH:10]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:19]([C:17]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:18]=1[N:9]=[CH:10][CH:11]=[CH:12]2)(=[O:20])=[O:21]

Participants

3

Reactant 2

HCID 292208-Quinolinesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 17770359N-(4-Bromo-3-methyl-5-isoxazolyl)-8-quinolinesulfonamideYield 62%

Procedure

N-(4-Bromo-3-methyl-5-isoxazolyl)-8-quinolinesulfonamide was prepared, in the same manner as described in Example 96, from 5-amino-4-bromo-3-methylisoxazole and 8-quinolinesulfonyl chloride in 62% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 169°-171° C.

Workup

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 169°-171° C.

Sources & evidence

ORD record
ord-1d1bcc01af754cb2ac6d0fc54776829a
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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