HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Quinolinesulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-8-quinolinesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Quinolinesulfonyl chloride | HCID 29220 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Product | N-(4-Bromo-3-methyl-5-isoxazolyl)-8-quinolinesulfonamide | HCID 17770359 | 62% |
Reaction Steps
N-(4-Bromo-3-methyl-5-isoxazolyl)-8-quinolinesulfonamide was prepared, in the same manner as described in Example 96, from 5-amino-4-bromo-3-methylisoxazole and 8-quinolinesulfonyl chloride in 62% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 169°-171° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571821 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-1d1bcc01af754cb2ac6d0fc54776829a |
| Source note | uspto-grants-1996_11 |