1-Naphthalenesulfonyl chloride → N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-1-naphthalenesulfonamide

HRID 1899694Notes

Reaction equation

HRID 1899694 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH3:11].[C:12]1([S:22](Cl)(=[O:24])=[O:23])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1>>[CH3:11][C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:22]([C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 665601-Naphthalenesulfonyl chlorideHCID 156138784-Methyl-3-(trifluoromethyl)isoxazol-5-amine

Product 1

HCID 23372919N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-1-naphthalenesulfonamideYield 85%

Procedure

N-(4-Methyl-3-trifluoromethyl-5-isoxazolyl)-1-naphthalenesulfonamide was prepared, as described in Example 90, from 5-amino-4-methyl-3-trifluoromethylisoxazole and 1-naphthalenesulfonyl chloride in 85% yield. Purification was achieved by recrystallization from methanol/water to give white needed, m.p. 154°-155° C.

Workup

  1. customPurification
  2. customwas achieved by recrystallization from methanol/water
  3. customto give white

Sources & evidence

ORD record
ord-5730c4a9f959427db5f063a3d44243eb
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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