反应详情

温度

60 °C

At 60° C. and while stirring, 11.6 g (0.19 mol of ethanolamine is added to 55.5 g (0.19 mol of the phthalimide ether c) in 190 ml of ethyl acetate. After 5 hours, the precipitated N-(hydroxyethyl)-phthalimide is filtered off and 18.8 g of oxalic acid in 30 ml of ethyl acetate is added to the filtrate. There is obtained 95% of theory of (E)-4-phenyl-2-butenyloxyamine as the oxalate salt. Melting point: 127°-129° C.

1. filtrationthe precipitated N-(hydroxyethyl)-phthalimide is filtered off
2. addition18.8 g of oxalic acid in 30 ml of ethyl acetate is added to the filtrate