HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 23371526, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]piperazine | HCID 9974013 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 23371526 | HCID 23371526 | — |
Reaction Steps
A solution of 5 g (0.015 mol) of 1-[2-[(4,4'-Difluorobenzhydryl)oxy]ethyl]piperazine. 50 ml toluene and 3 ml (0.02 mol) triethylamine was added dropwise to a solution of 1.5 g (0.005 mol) triphosgene in 100 ml toluene at 5°-10° C. for 1 h. The mixture was allowed to stand at room temperature for 16 h and then washed with 1-N NaOH and water, dried over sodium sulphate. Evaporation of the solvent yielded the crude base as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05574031 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-397a8824204b4ed3adfb18ec8c356888 |
| Source note | uspto-grants-1996_11 |