Triethylamine → HCID 23371526, compound

HRID 1899799Notes

Reaction equation

HRID 1899799 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH:6]([O:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH2:25]([N:27]([CH2:30][CH3:31])[CH2:28]C)[CH3:26].[Cl:32]C(Cl)([O:35]C(=O)OC(Cl)(Cl)Cl)Cl>C1(C)C=CC=CC=1>[ClH:32].[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]([O:14][CH2:15][CH2:16][N:17]2[CH2:18][CH2:19][N:20]([C:28](=[O:35])[N:27]([CH2:30][CH3:31])[CH2:25][CH3:26])[CH2:21][CH2:22]2)[C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)=[CH:23][CH:24]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 94429TriphosgeneHCID 99740131-[2-[Bis(4-fluorophenyl)methoxy]ethyl]piperazine

Product 1

HCID 23371526HCID 23371526, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 5 g (0.015 mol) of 1-[2-[(4,4'-Difluorobenzhydryl)oxy]ethyl]piperazine. 50 ml toluene and 3 ml (0.02 mol) triethylamine was added dropwise to a solution of 1.5 g (0.005 mol) triphosgene in 100 ml toluene at 5°-10° C. for 1 h. The mixture was allowed to stand at room temperature for 16 h and then washed with 1-N NaOH and water, dried over sodium sulphate. Evaporation of the solvent yielded the crude base as an oil.

Workup

  1. washwashed with 1-N NaOH and water
  2. dry with materialdried over sodium sulphate
  3. customEvaporation of the solvent

Sources & evidence

ORD record
ord-397a8824204b4ed3adfb18ec8c356888
Source dataset
uspto-grants-1996_11
Patent number
US05574031

Reaction notes

Loading…