Trimethyl phosphite → HCID 53876594, compound

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Reaction Steps

Chlorovaleric acid (5.0 g, 0.037 moles) is dissolved in 40ml of dry methylene chloride in a round bottom flask under a nitrogen atmosphere. Freshly distilled oxalyl chloride (9.58 ml, 0.110 moles) is added and the mixture is stirred overnight. The solution is concentrated under vacuum to dryness to yield 5.15 g of chlorovaleryl chloride. Trimethylphosphite (3.9 ml, 0.033 mole) is slowly added to chlorovaleryl chloride (5.15 g, 0.033 mole) under a continuous flow of nitrogen. The mixture is allowed to stir overnight to yield 7.15 g of dimethyl chlorovalerylphosphonate.

Provenance & Evidence