Trimethyl phosphite → HCID 53876594, compound
Reaction equation
C[O:2][P:3]([O:6][CH3:7])[O:4][CH3:5].[Cl:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](Cl)=[O:14]>>[Cl:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([P:3](=[O:2])([O:6][CH3:7])[O:4][CH3:5])=[O:14]Participants
3
Procedure
Chlorovaleric acid (5.0 g, 0.037 moles) is dissolved in 40ml of dry methylene chloride in a round bottom flask under a nitrogen atmosphere. Freshly distilled oxalyl chloride (9.58 ml, 0.110 moles) is added and the mixture is stirred overnight. The solution is concentrated under vacuum to dryness to yield 5.15 g of chlorovaleryl chloride. Trimethylphosphite (3.9 ml, 0.033 mole) is slowly added to chlorovaleryl chloride (5.15 g, 0.033 mole) under a continuous flow of nitrogen. The mixture is allowed to stir overnight to yield 7.15 g of dimethyl chlorovalerylphosphonate.
Sources & evidence
- ORD record
- ord-f1107482154a4085981b0bc8dd6c37c4
- Source dataset
- uspto-grants-1996_11
- Patent number
- US05574024
Reaction notes
Loading…