Fumaric Acid → HCID 67623101, compound

HRID 1899832Notes

Reaction equation

HRID 1899832 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH:9]([N:16]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:18][C:17]2=[O:27])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:3][CH2:2]1.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32]>C(O)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH:9]([N:16]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:18][C:17]2=[O:27])[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 53927178HCID 53927178, compound

Product 1

HCID 67623101HCID 67623101, compoundYield 61.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diastereomer A of 3-(3-morpholino-1-phenylpropyl)-5-phenyl-1,3-oxazolidin-2-one (480 mg, 1.31 mmol) prepared in the same manner as is described in Example 7 and fumaric acid (152 mg, 1.31 mmol) were dissolved in ethanol (30 ml). The resulting solution was concentrated by distillation under reduced pressure to obtain 389 mg of the titled compound as a pale yellow amorphous product (yield: 61.5%).

Workup

  1. concentrationThe resulting solution was concentrated by distillation under reduced pressure

Sources & evidence

ORD record
ord-349d4d86b2c84d1abeba56208a0ee6df
Source dataset
uspto-grants-1996_11
Patent number
US05574030

Reaction notes

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