反应详情

温度

60 °C

To a suspension of 8-(3-amino-2,6-dichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine dihydrochloride (200 mg), pyridine (1 ml) and N-methylpyrrolidone (3 ml) was added propionyl chloride (78 mg) and the mixture was stirred at 60° C. for 1 hour. To the cooled mixture was added water, and the precipitate was collected by filtration and dissolved in chloroform. This organic solution was washed with water and brine respectively, dried with magnesium sulfate and concentrated in vacuo. The residue was collected by filtration and washed with ethyl acetate to give 3-bromo-8-(2,6-dichloro-3-propionylaminobenzyloxy)-2-methylimidazo[1,2-a]pyridine (158 mg).

1. filtrationthe precipitate was collected by filtration
2. dissolutiondissolved in chloroform
3. washThis organic solution was washed with water and brine respectively
4. dry with materialdried with magnesium sulfate
5. concentrationconcentrated in vacuo
6. filtrationThe residue was collected by filtration
7. washwashed with ethyl acetate