huagongshe.com
HRID1900

反应详情

EQUATION

反应方程式

HRID 1900 的结构方程式

REACTANTS

反应物

4
结构：CC(C)(C)O
HCID6386

tert-Butyl alcohol

C4H10O

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1
HCID199401

Phosphinic azide, diphenyl-

C12H10N3OP

结构：CCOC(=O)c1cc(C2CC2)c2c(C)c(C3(C(=O)O)CC3)c(F)cn2c1=O
HCID57128975

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)c1cc(C2CC2)c2c(C)c(C3(NC(=O)OC(C)(C)C)CC3)c(F)cn2c1=O
HCID57102320

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A sample of the product from Step 477d is heated with diphenylphosphoryl azide, t-butanol, triethylamine and dioxane. The solvents is removed under vacuum. The residue is dissolved in methylene chloride, washed with water and dried over MgSO4 and concentrated under vacuum. The title compound is purified by chromatography on silica gel.

WORKUP

后处理

  1. customThe solvents is removed under vacuum
  2. dissolutionThe residue is dissolved in methylene chloride
  3. washwashed with water
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated under vacuum
  6. customThe title compound is purified by chromatography on silica gel