反应详情

A suspension of 500 mg (1.84 mmol) of trans-[4-(4-cyano-cyclohexyl)-phenyl]-ethoxycarbamic acid, 365 mg (2.8 mmol) of (S)-4-methoxymethyl-1,3-dioxolan-2-one and 185 mg of potassium carbonate was stirred at 160° for 16 hours. The reaction mixture was chromatographed over silica gel with ethyl acetate/hexane 1:1 and the yellow crystals obtained were recrystallized from ethyl acetate. 165 mg (29%) were obtained as white crystals with m.p. 174°.

1. customThe reaction mixture was chromatographed over silica gel with ethyl acetate/hexane 1:1
2. customthe yellow crystals obtained
3. customwere recrystallized from ethyl acetate
4. custom165 mg (29%) were obtained as white crystals with m.p. 174°