Hydrogen Bromide → HCID 19043706, compound

HRID 1900140Notes

Reaction equation

HRID 1900140 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17]C)=[C:13]([F:19])[CH:12]=1)=[O:10].Br>C(O)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([F:19])[CH:12]=1)=[O:10]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 19043724HCID 19043724, compound

Product 1

HCID 19043706HCID 19043706, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 3.9g of (2,6-difluoro-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone (paragraph Hd)) in 30 ml of acetic acid is stirred with 20 ml of aqueous 62% HBr solution at 125° C., then evaporated, re-evaporated with toluene and taken up in ethyl acetate. The organic phase is washed with sat. aqueous NaHCO3 solution and 10% NaCl solution and then dried. 3.6g of (2,6-difluoro-phenyl)-(3-fluoro-4-hydroxy-phenyl)-methanone MS: m/e 252 (M+), are obtained.

Workup

  1. customevaporated
  2. customre-evaporated with toluene
  3. washThe organic phase is washed with sat. aqueous NaHCO3 solution and 10% NaCl solution
  4. customdried

Sources & evidence

ORD record
ord-f14c8aea515c4c7a8bf8994c9c2515be
Source dataset
uspto-grants-1996_11
Patent number
US05574071

Reaction notes

Loading…