反应详情

Hydrogen chloride gas was introduced into a solution containing 3.7 g of N2-tert-butoxycarbonyl-N1 -[2-(4-cyanophenoxy)-1-methylethyl]-L-valinamide dissolved in 100 mL of methylene chloride for 1 hour at room temperature. After completion of the reaction, the methylene chloride was removed under reduced pressure, thus obtaining a crude crystal. The crude crystal was washed with acetone to afford 3.1 g of the desired product (yield: 100%). Melting point: 59°-63° C.

1. customAfter completion of the reaction
2. customthe methylene chloride was removed under reduced pressure
3. customthus obtaining a crude crystal
4. washThe crude crystal was washed with acetone