Hydrochloric Acid → HCID 67726688, compound

HRID 1900236Notes

Reaction equation

C(OC([NH:8][CH2:9][C:10]12[CH2:17][N:16]([C:18]3[C:27]([Cl:28])=[C:26]4[C:21]([C:22](=[O:36])[C:23]([C:33]([OH:35])=[O:34])=[CH:24][N:25]4[C@@H:29]4[CH2:31][C@@H:30]4[F:32])=[CH:20][C:19]=3[F:37])[CH2:15][CH:14]1[CH2:13][CH2:12][O:11]2)=O)(C)(C)C.Cl>>[ClH:28].[NH2:8][CH2:9][C:10]12[CH2:17][N:16]([C:18]3[CH:27]=[C:26]4[C:21]([C:22](=[O:36])[C:23]([C:33]([OH:35])=[O:34])=[CH:24][N:25]4[C@@H:29]4[CH2:31][C@@H:30]4[F:32])=[CH:20][C:19]=3[F:37])[CH2:15][CH:14]1[CH2:13][CH2:12][O:11]2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 54341473HCID 54341473, compound

Product 1

HCID 67726688HCID 67726688, compound

Procedure

In an analogous manner to Example 1B, the product from step A is reacted with half-concentrated hydrochloric acid to give 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]-oct-7-yl)-6-fluoro-1-(cis-2-fluorocyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride with a melting point of 180°-185° C. (with decomposition).

Sources & evidence

ORD record: ord-ea023d467c7f439b99ddfa33bf0d94d2
Source dataset: uspto-grants-1996_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05574161

Reaction notes

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