Hydrochloric Acid → HCID 67726995, compound

HRID 1900238Notes

Reaction equation

C(OC([NH:8][CH2:9][C:10]12[CH2:17][N:16]([C:18]3[C:19]([F:36])=[CH:20][C:21]4[C:31](=[O:32])[C:30]([C:33]([OH:35])=[O:34])=[CH:29][N:23]5[CH:24]([CH3:28])[CH2:25][O:26][C:27]=3[C:22]=45)[CH2:15][CH:14]1[CH2:13][CH2:12][O:11]2)=O)(C)(C)C.[ClH:37]>>[ClH:37].[NH2:8][CH2:9][C:10]12[CH2:17][N:16]([C:18]3[C:19]([F:36])=[CH:20][C:21]4[C:31](=[O:32])[C:30]([C:33]([OH:35])=[O:34])=[CH:29][N:23]5[CH:24]([CH3:28])[CH2:25][O:26][C:27]=3[C:22]=45)[CH2:15][CH:14]1[CH2:13][CH2:12][O:11]2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19960954HCID 19960954, compound

Product 1

HCID 67726995HCID 67726995, compound

Procedure

In an analogous manner to Example 1B, the product from step A is reacted with half-concentrated hydrochloric acid to give 10-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride with a melting point of 220°-227° C. (with decomposition).

Sources & evidence

ORD record: ord-24a90b27ecd74f6d8c98546d9b1b52c2
Source dataset: uspto-grants-1996_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05574161

Reaction notes

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