(-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine → HCID 23372082, compound

HRID 1900276Notes

Reaction equation

HRID 1900276 reaction equation
C(N1C[C@H](C)NC[C@H]1C)C=C.N1C2C=CC=CC=2N=N1.[F:21][C:22]1[CH:23]=[C:24]([N:28]([CH3:39])[C:29](=[O:38])[C:30]2[CH:35]=[CH:34][CH:33]=[C:32](C=O)[CH:31]=2)[CH:25]=[CH:26][CH:27]=1>C1(C)C=CC=CC=1>[F:21][C:22]1[CH:23]=[C:24]([N:28]([CH3:39])[C:29](=[O:38])[C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:25]=[CH:26][CH:27]=1

Participants

5

Reactant 3

HCID 10534891(-)-(2R,5S)-1-allyl-2,5-dimethylpiperazineHCID 21480428HCID 21480428, compoundHCID 178418385HCID 178418385, compound

Product 1

HCID 23372082HCID 23372082, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Crude 3-((2R,5S)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-(1H-benzotriazol-1-yl)methyl)-N-(3-fluorophenyl)-N-methylbenzamide was prepared from (2R,5S)-1-allyl-2,5-dimethylpiperazine (1.89 g), benzotriazole (1.39 g), and N-(3-fluorophenyl)-3-formyl-N-methylbenzamide (3.0 g) in toluene as described in Example 16. Method B.

Sources & evidence

ORD record
ord-d786da050ed54eb88a5c05972dad329f
Source dataset
uspto-grants-1996_11
Patent number
US05574159

Reaction notes

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