Hydrochloric Acid → HCID 23369420, compound

HRID 1900550Notes

Reaction equation

HRID 1900550 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:30])[CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=2)[CH2:16][CH2:15]1)([O-])=O.Cl>[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:30])[CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][N:17]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=2)[CH2:18][CH2:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 33473794N-(2-Nitrophenyl)-4-(3-trifluoromethylphenyl)-1-piperazinpropionamide

Product 1

HCID 23369420HCID 23369420, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The compound was prepared according to the method described in J. Med. Chem. 30, 13 (1987) by catalytic reduction of N-(2-nitrophenyl)-4-(3-trifluoromethylphenyl)-1-piperazin propionamide in the presence of 10% Pd/C. Monohydrochloride salt. M.p. 194°-196° C.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-43adb1a57b9e4e6ea1dee0d76da8c80f
Source dataset
uspto-grants-1996_11
Patent number
US05576318

Reaction notes

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