Hydrochloric Acid → 3-Acetamidopyrrolidine

HRID 1900605Notes

Reaction equation

HRID 1900605 reaction equation
[C:1]([NH:4][CH2:5][CH:6]1[CH2:9][N:8]([CH:10](C2C=CC=CC=2)C2C=CC=CC=2)C1)(=[O:3])[CH3:2].Cl>[Pd].C(O)C>[C:1]([NH:4][CH:5]1[CH2:6][CH2:9][NH:8][CH2:10]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23369480HCID 23369480, compound

Product 1

HCID 5227153-AcetamidopyrrolidineYield 89%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 12.5 g (0.057 mol) of the compound obtained in stage c) above, 1.3 g of 10% Pd/C, 80 ml of 95% ethanol and a drop of concentrated hydrochloric acid is hydrogenated at 40° C. When the theoretical quantity of hydrogen has been consumed, it is filtered and the filtrate is concentrated to obtain 6.5 g of the title compound in the form of an oily product.

Workup

  1. customis hydrogenated at 40° C
  2. customWhen the theoretical quantity of hydrogen has been consumed
  3. filtrationit is filtered
  4. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-1a928d4b37604e8baac71fe30740b07e
Source dataset
uspto-grants-1996_11
Patent number
US05576320

Reaction notes

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