反应详情

10 ml of ethanol, 5 ml of water and 820 mg of sodium hydroxide were added to 1 g of 2-(4-ethoxy-carbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline. The obtained mixture was refluxed for 20 minutes, concentrated under a reduced pressure and neutralized with 1N hydrochloric acid. The crystals thus precipitated were recovered by filtration to give 920 mg of the title compound.

1. temperatureThe obtained mixture was refluxed for 20 minutes
2. concentrationconcentrated under a reduced pressure and neutralized with 1N hydrochloric acid
3. customThe crystals thus precipitated
4. filtrationwere recovered by filtration