Hydrochloric Acid → HCID 23369581, compound

Participants

Reaction Steps

2-(t-Butoxycarbonyl)aminomethyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one (416 mg) was dissolved in tetrahydrofuran (8.8 ml), to which 6N-HCl (2.2 ml) was added. The mixture was refluxed for 30 minutes while heating. After completion of the reaction, the mixture was dried to solidity under reduced pressure. The residue was subjected to recrstallization with a solvent mixture of methanol-ether to obtain 265 mg of a hydrochloric acid salt of 2-aminomethyl-5-chloro-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one as light yellow powdery crystals (79.6%,

Provenance & Evidence