Hydrochloric Acid → HCID 23369581, compound

HRID 1900723Notes

Reaction equation

HRID 1900723 reaction equation
C(OC([NH:8][CH2:9][CH:10]1[O:23][C:13]2=[C:14]3[C:19](=[CH:20][CH:21]=[C:12]2[CH2:11]1)[NH:18][C:17](=[O:22])[CH:16]=[CH:15]3)=O)(C)(C)C.[ClH:24]>O1CCCC1>[NH2:8][CH2:9][CH:10]1[O:23][C:13]2=[C:14]3[C:19](=[C:20]([Cl:24])[CH:21]=[C:12]2[CH2:11]1)[NH:18][C:17](=[O:22])[CH:16]=[CH:15]3

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23369689HCID 23369689, compound

Product 1

HCID 23369581HCID 23369581, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-(t-Butoxycarbonyl)aminomethyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one (416 mg) was dissolved in tetrahydrofuran (8.8 ml), to which 6N-HCl (2.2 ml) was added. The mixture was refluxed for 30 minutes while heating. After completion of the reaction, the mixture was dried to solidity under reduced pressure. The residue was subjected to recrstallization with a solvent mixture of methanol-ether to obtain 265 mg of a hydrochloric acid salt of 2-aminomethyl-5-chloro-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one as light yellow powdery crystals (79.6%,

Workup

  1. additionwas added
  2. temperatureThe mixture was refluxed for 30 minutes
  3. temperaturewhile heating
  4. customAfter completion of the reaction
  5. customthe mixture was dried to solidity under reduced pressure
  6. additionThe residue was subjected to recrstallization with a solvent mixture of methanol-ether

Sources & evidence

ORD record
ord-fa88f6b25ed14e28bb64ce87acc9f04f
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

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