Water → HCID 23369706, compound

HRID 1900739Notes

Reaction equation

HRID 1900739 reaction equation
CS(O[CH2:6][CH:7]1[O:19][C:18]2[C:9](=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:20])[CH:12]=[CH:11]3)[CH2:8]1)(=O)=O.[N-:21]=[N+:22]=[N-:23].[Na+].O>CN(C)C=O>[N:21]([CH2:6][CH:7]1[O:19][C:18]2[C:9](=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:20])[CH:12]=[CH:11]3)[CH2:8]1)=[N+:22]=[N-:23]

Participants

5

Reactant 3

HCID 962WaterHCID 33557Sodium AzideHCID 23369734HCID 23369734, compound

Product 1

HCID 23369706HCID 23369706, compoundYield 89.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

The compound obtained in Example 157 (1.0 g, 3.37 mmol) and sodium azide (1.9 g, 33.7 mmol) were suspended in dimethylformamide (20 ml). The suspension was stirred at 100° C. for 2 hours, followed by cooling. The reaction mixture was combined with water, and the precipitated crystals were collected by filtration and washed with water. 0.733 g of the title compound was obtained as pale brown crystals (89.4%, mp.: 194° C. (dec.)).

Workup

  1. temperatureby cooling
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-46017321404c4fb2bc8761b86343ae71
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

Loading…