反应详情

温度

100 °C

A mixture of 2-bromomethyl-5-methyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one (0.882 g), potassium thiocyanate (2.915 g) and dimethylformamide (40 ml) was stirred in a hot bath at 100° C. for 5 hours. The solvent was distilled off under reduced pressure. The residue was combined with water and extracted with chloroform. The chloroform extract liquid was washed with water, dried and condensed. The residue was crystallized from chloroform--n-hexane to obtain 0.683 g of the title compound as white powder (mp.: 227°-229° C. (dec.)).

1. distillationThe solvent was distilled off under reduced pressure
2. extractionextracted with chloroform
3. extractionThe chloroform extract liquid
4. washwas washed with water
5. customdried
6. customcondensed
7. customThe residue was crystallized from chloroform