反应详情

To a suspension of 2-bromomethyl-5-methyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one (0.882 g) in dimethylformamide (40 ml), cysteamine hydrochloride (3.41 g) and caustic soda (2.40 g) in water (20 ml) were added and stirred at room temperature for 1 hour. The solvent was distilled off under reduced pressure. The residue was combined with water, and extracted with chloroform. The extract was washed with water and dried. The solvent was evaporated and the residue was crystallized from chloroform--n-hexane to obtain 0.714 g of the title compound as pale yellow prisms (mp.: 182°-184° C.).

1. additionwere added
2. distillationThe solvent was distilled off under reduced pressure
3. extractionextracted with chloroform
4. washThe extract was washed with water
5. customdried
6. customThe solvent was evaporated
7. customthe residue was crystallized from chloroform