HCID 23369730, compound → HCID 23369779, compound

HRID 1900792Notes

Reaction equation

HRID 1900792 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[O:20][C:9]2=[C:10]3[C:15](=[C:16]([CH3:18])[CH:17]=[C:8]2[CH2:7]1)[NH:14][C:13](=[O:19])[CH:12]=[CH:11]3)=[O:5])[CH3:2].[H][H]>C(O)(=O)C.[Pd]>[CH2:1]([O:3][C:4]([CH:6]1[O:20][C:9]2=[C:10]3[C:15](=[C:16]([CH3:18])[CH:17]=[C:8]2[CH2:7]1)[NH:14][C:13](=[O:19])[CH2:12][CH2:11]3)=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 23369730HCID 23369730, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23369779HCID 23369779, compoundYield 99.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 176Acetic AcidSolvent

Procedure

The compound obtained in Example 257 (3 g, 11 mmol) was dissolved in acetic acid (50 ml). To the solution, 10% palladium-on-carbon (3 g) was added, followed by stirring at 80° C. for 4 hours in the stream of hydrogen to carry out hydrogenation. After completion of the reaction, palladium-on-carbon was removed by filtration. The filtrate was thoroughly washed with chloroform and methanol, and condensed. As a result, 3 g of the title compound was obtained as a white solid (99%).

Workup

  1. customwas removed by filtration
  2. washThe filtrate was thoroughly washed with chloroform and methanol, and condensed

Sources & evidence

ORD record
ord-2bb6aac37e01411abd3082715001f8b0
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

Loading…