Hydrochloric Acid → HCID 67802137, compound

HRID 1900816Notes

Reaction equation

HRID 1900816 reaction equation
[ClH:1].[NH2:2][CH2:3][C:4]1([CH3:20])[O:19][C:7]2=[C:8]3[C:13](=[C:14]([CH3:16])[CH:15]=[C:6]2[CH2:5]1)[NH:12][C:11](=[O:17])[C:10]([CH3:18])=[CH:9]3.[H][H]>O.CO.[Pd]>[NH2:2][CH2:3][C:4]1([CH3:20])[O:19][C:7]2=[C:8]3[C:13](=[C:14]([CH3:16])[CH:15]=[C:6]2[CH2:5]1)[NH:12][C:11](=[O:17])[CH:10]([CH3:18])[CH2:9]3.[ClH:1]

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 23369839HCID 23369839, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67802137HCID 67802137, compoundYield 80.6%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A hydrochloric acid salt of 2-Aminomethyl-2,5,8-trimethyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one (1.18 g, 4.0 mmol) was suspended in a mixture of water (200 ml) and methanol (40 ml), to which 10% palladium-on-carbon (1.2 g) was added. The mixture was then stirred in a bath at 80° C. for 16 hours in the atmosphere of hydrogen. Post-treatment and recrystallization (methanol-ether) were performed in a manner similar to that described in Example 280 to obtain 957 mg of the title compound as colorless crystals (80.6%).

Workup

  1. additionwas added
  2. customPost-treatment and recrystallization (methanol-ether)

Sources & evidence

ORD record
ord-dc36d9c7368c4c9fb568c254c955af51
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

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