HCID 23369740, compound → HCID 23369813, compound

HRID 1900826Notes

Reaction equation

HRID 1900826 reaction equation
[N:1]([CH2:4][CH:5]1[O:20][C:8]2=[C:9]3[C:14](=[C:15]([CH3:17])[CH:16]=[C:7]2[CH:6]1[CH2:21][CH3:22])[NH:13][C:12](=[O:18])[C:11]([CH3:19])=[CH:10]3)=[N+]=[N-]>[Pd].CN(C)C=O>[NH2:1][CH2:4][CH:5]1[O:20][C:8]2=[C:9]3[C:14](=[C:15]([CH3:17])[CH:16]=[C:7]2[CH:6]1[CH2:21][CH3:22])[NH:13][C:12](=[O:18])[C:11]([CH3:19])=[CH:10]3

Participants

4

Reactant 1

HCID 23369740HCID 23369740, compound

Product 1

HCID 23369813HCID 23369813, compoundYield 57.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared in a manner similar to that described in Example 275 using the compound obtained in Example 293 (21 mg, 0. 070 mmol), 10% palladium-on-carbon (10 mg) and dimethylformamide (0.6 ml). 11 mg of the title compound was obtained as colorless crystals (57.4%). The crystals were purified by silica gel column chromatography to obtain the cis- form of the title compound as colorless powdery crystals (mp. 209°-225° C.) and the trans- form of the title compound as colorless powdery crystals (mp. 142°-155° C.).

Workup

  1. customThe title compound was prepared in a manner similar to

Sources & evidence

ORD record
ord-2ba0c3c373ea4e4bbba8e53bc0c0e0b3
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

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