Acetic Acid → HCID 23369836, compound

HRID 1900846Notes

Reaction equation

HRID 1900846 reaction equation
Cl[C:2]1[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]2[C:4](=[C:5]([CH3:17])[CH:6]=[CH:7][C:8]=2[O:15][CH3:16])[N:3]=1.C(O)(=[O:20])C>>[CH:12]([C:11]1[C:2](=[O:20])[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([O:15][CH3:16])[CH:7]=[CH:6][C:5]=2[CH3:17])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 23369770HCID 23369770, compound

Product 1

HCID 23369836HCID 23369836, compound

Conditions

Temperature
120 °C

Procedure

2-Chloro-3-isopropyl-5-methoxy-8-methylquinoline (2.65 g, 10.6 mmol) was dissolved in acetic acid (70 ml), and the solution was stirred at 120° C. for 15 hours. The reaction solution was condensed under reduced pressure, and the resultant residue was recrystallized from chloroform-ethyl acetate. 2.10 g of the title compound was obtained as pale yellow powdery crystals (85.6%).

Workup

  1. customcondensed under reduced pressure
  2. customthe resultant residue was recrystallized from chloroform-ethyl acetate

Sources & evidence

ORD record
ord-cceb78aa6b834baa83bfc144773ef5b2
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

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