2-Fluoro-4-nitrophenol → HCID 54471961, compound

Participants

Reaction Steps

In a similar manner to Example 2, starting material step (b), t-butyl bromoacetate (5.6 ml), 2-fluoro-4-nitrophenol (5 g), anhydrous potassium carbonate (5.3 g) and acetone (200 ml) were reacted to give t-butyl 2-fluoro-4-nitrophenoxyacetate (8.3 g) as an off-white solid: m.p. 62°-64° C.; NMR Spectrum (DMSO-d6) 1.49 (9H, s), 4.70 (2H, s), 6.94 (1H, m), 8.01 (2H, m); Mass Spectrum m/Z 272 (M+H)+.

Provenance & Evidence