2-Fluoro-4-nitrophenol → HCID 54471961, compound

HRID 1900890Notes

Reaction equation

HRID 1900890 reaction equation
Br[CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[F:10][C:11]1[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=1[OH:20].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:10][C:11]1[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=1[O:20][CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4]

Participants

5

Reactant 3

HCID 98252-Fluoro-4-nitrophenolHCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetate

Product 1

HCID 54471961HCID 54471961, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In a similar manner to Example 2, starting material step (b), t-butyl bromoacetate (5.6 ml), 2-fluoro-4-nitrophenol (5 g), anhydrous potassium carbonate (5.3 g) and acetone (200 ml) were reacted to give t-butyl 2-fluoro-4-nitrophenoxyacetate (8.3 g) as an off-white solid: m.p. 62°-64° C.; NMR Spectrum (DMSO-d6) 1.49 (9H, s), 4.70 (2H, s), 6.94 (1H, m), 8.01 (2H, m); Mass Spectrum m/Z 272 (M+H)+.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-487982f8227d41639a103f35dd25a131
Source dataset
uspto-grants-1996_11
Patent number
US05576334

Reaction notes

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