Hydrogen Sulfide → HCID 23370051, compound

HRID 1900891Notes

Reaction equation

HRID 1900891 reaction equation
[C:1]([C:3]1[CH:30]=[CH:29][C:6]([C:7]([NH:9][C:10](=[O:28])[NH:11][C:12]2[CH:26]=[CH:25][C:15]([O:16][CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[C:14]([F:27])[CH:13]=2)=[O:8])=[CH:5][CH:4]=1)#[N:2].N1C=CC=CC=1.[SH2:37]>C(N(CC)CC)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][C:10](=[O:28])[NH:11][C:12]2[CH:26]=[CH:25][C:15]([O:16][CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[C:14]([F:27])[CH:13]=2)=[O:8])=[CH:29][CH:30]=1)(=[S:37])[NH2:2]

Participants

5

Reactant 3

HCID 402Hydrogen SulfideHCID 1049PyridineHCID 23370035HCID 23370035, compound

Product 1

HCID 23370051HCID 23370051, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a similar manner to Example 1, starting material step (b), the product of step (c) (504 mg), pyridine (35 ml), triethylamine (5 ml) and H2S gas were reacted to give t-butyl 4-[3-(4-thiocarbamoylbenzoyl)ureido]-2-fluorophenoxyacetate (509 mg): m/Z 447 (M)+. ; 460 (M+Na)+.

Sources & evidence

ORD record
ord-cc5c29cd8f814824a46cb7cb53bf5508
Source dataset
uspto-grants-1996_11
Patent number
US05576334

Reaction notes

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