Potassium Carbonate → HCID 21268313, compound

HRID 1901016Notes

Reaction equation

HRID 1901016 reaction equation
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([C:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH:18]=3)=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl[CH2:20][CH2:21][CH2:22][O:23][C:24]1[C:25]2[CH:26]=[CH:27][NH:28][C:29]=2[CH:30]=[CH:31][CH:32]=1.C(=O)([O-])[O-].[K+].[K+]>>[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([C:13]3[CH2:14][CH2:15][N:16]([CH2:20][CH2:21][CH2:22][O:23][C:24]4[CH:32]=[CH:31][CH:30]=[C:29]5[C:25]=4[CH:26]=[CH:27][NH:28]5)[CH2:17][CH:18]=3)=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 116941694-(3-chloropropoxy)-1H-indoleHCID 21268269HCID 21268269, compound

Product 1

HCID 21268313HCID 21268313, compound

Procedure

The title compound was prepared in a fashion similar to that described in Example 192 from 6-nitro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.50 g, 2.1 mmol), 1-chloro-3-(1H-indole-4-oxy)propane (0.43 g, 2.1 mmol) and potassium carbonate (0.32 g, 2.3 mmol). The product was isolated as an orange granular solid. Yield 0.49 g (56%). mp 215°-225° C. FDMS m/e=416 (M+ of free base).

Workup

  1. customThe product was isolated as an orange granular solid

Sources & evidence

ORD record
ord-7e5aac76534d4ebe801ac6b95ee78c61
Source dataset
uspto-grants-1996_11
Patent number
US05576321

Reaction notes

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