Hydrogen chloride-ethyl acetate → HCID 23370133, compound

HRID 1901042Notes

Reaction equation

HRID 1901042 reaction equation
[CH3:1][N:2]([CH3:29])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:28])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[NH:17][C:18]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:19])=[CH:5][CH:4]=1.[ClH:30].C(OCC)(=O)C>C(O)C>[ClH:30].[CH3:29][N:2]([CH3:1])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:28])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[NH:17][C:18]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:19])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 23370093HCID 23370093, compound

Product 1

HCID 23370133HCID 23370133, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of N-(4-dimethylaminophenyl)-2-(3-heptylureido)benzamide (0.70 g) in ethanol (10 ml) was added 4N-HCl/ethyl acetate solution (0.48 ml) under ice-cooling, and the mixture was concentrated to dryness to give N-(4-dimethylaminophenyl)-2-(3-heptylureido)benzamide monohydrochloride (0.77 g, 99%) as a non-crystallizable solid.

Workup

  1. temperaturecooling
  2. concentrationthe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-6da0f5422460465db283bbdc34e78157
Source dataset
uspto-grants-1996_11
Patent number
US05576335

Reaction notes

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