反应详情

Phenyl N-[2-(3,5-di-t-butyl-4-hydroxybenzoylamino)phenyl]carbamate (1.6 g) and dibenzylamine (0.7 g) were dissolved in benzene (10 ml) and stirred at 70°-80°0 C. for 2 hrs. The reaction solution was washed with 2N sodium hydroxide, saturated ammonium chloride solution, dried over anhydrous NaSO4 and the solvent was distilled off. Purification of the residue by a silica gel column chromatography followed by crystallization from ether afforded N-[2-(3,3-dibenzylureido )phenyl]-3,5-di-t-butyl-4-hydroxybenzamide (0.47 g, 23%).

1. washThe reaction solution was washed with 2N sodium hydroxide, saturated ammonium chloride solution
2. dry with materialdried over anhydrous NaSO4
3. distillationthe solvent was distilled off
4. customPurification of the residue by a silica gel column chromatography
5. customfollowed by crystallization from ether