1-(4-Methoxy-2-nitrophenyl)-3-cyclopentylurea → 1-(2-Amino-4-methoxyphenyl)-3-cyclopentylurea

Participants

Reaction Steps

To a suspension of 1-(4-methoxy-2-nitrophenyl)-3-cyclopentylurea (0.96 g) in ethanol (15 ml) was added a catalytic amount of 10% palladium/carbon to carry out catalytic reduction at a pressure of 1-2.5 arms at room temperature for 2 hrs. The catalyst was filtered off, the solvent was distilled off and crystallization of the residue from benzene and hexane afforded 1-(2-amino-4-methoxyphenyl)-3-cyclopentylurea (0.79 g, 93%).

Provenance & Evidence