HCID 23370135, compound → HCID 23370063, compound

HRID 1901067Notes

Reaction equation

HRID 1901067 reaction equation
[N+:1]([C:4]1[C:5]([NH:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:12])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[C:5]([NH:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:12])=[N:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 23370135HCID 23370135, compound

Product 1

HCID 23370063HCID 23370063, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a suspension of 1-(3-nitro-2-pyridyl)-3-heptylurea (1.00 g) in ethanol (10 ml) was added a catalytic amount of 10% palladium/carbon to perform catalytic reduction under 1-2.5 atms at room temperature for 5 hrs. After filtering the catalyst and distilling off the solvent, the crystallization of the residue from hexane afforded 1-(3-amino-2-pyridyl)-3-heptylurea (0.89 g, 99%).

Workup

  1. customat room temperature
  2. customfor 5 hrs
  3. filtrationAfter filtering the catalyst
  4. distillationdistilling off the solvent
  5. customthe crystallization of the residue from hexane

Sources & evidence

ORD record
ord-7d9c5c35abe14e679ee5eecd8191a103
Source dataset
uspto-grants-1996_11
Patent number
US05576335

Reaction notes

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