3,4-Diaminopyridine → HCID 23370121, compound

HRID 1901069Notes

Reaction equation

HRID 1901069 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[CH2:9]([N:16]=[C:17]=[O:18])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>CN(C)C1C=CN=CC=1.C1(C)C=CC=CC=1>[NH2:8][C:7]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[NH:1][C:17]([NH:16][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[O:18]

Participants

5

Reactant 2

HCID 59183,4-DiaminopyridineHCID 138341n-Heptyl isocyanate

Product 1

HCID 23370121HCID 23370121, compoundYield 43.6%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1140TolueneSolvent

Procedure

A mixture of 3,4-diaminopyridine (1.09 g), heptyl isocyanate (1.41 g) and 4-dimethylaminopyridine (0.37 g) was stirred in toluene (10 ml) at 50°-60° C. for 5 hrs. The solvent was distilled off and the residue was purified by a silica gel column chromatography (chloroform:methanol=4:1) to give 1-(4-amino-3-pyridyl)-3-heptylurea (1.09 g, 37%) and crystals.

Workup

  1. distillationThe solvent was distilled off
  2. customthe residue was purified by a silica gel column chromatography (chloroform:methanol=4:1)

Sources & evidence

ORD record
ord-7038befec73b4bcdb66c4015b842a18f
Source dataset
uspto-grants-1996_11
Patent number
US05576335

Reaction notes

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