HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-N-Boc-4-Piperidinecarboxylic acid methyl ester → 1-(1,1-Dimethylethyl) 4-methyl 4-[(2-methylphenyl)methyl]-1,4-piperidinedicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-N-Boc-4-Piperidinecarboxylic acid methyl ester | HCID 392870 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Product | 1-(1,1-Dimethylethyl) 4-methyl 4-[(2-methylphenyl)methyl]-1,4-piperidinedicarboxylate | HCID 53775443 | — |
Reaction Steps
N-t-butoxycarbonyl isonipecotic acid methyl ester was transformed utilizing the alkylation procedure as described in Example 1, Step 3 substituting lithium diisopropylamide as the base to afford the product as a yellow syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576313 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-67a1997ccb744cdfa71453a4fdff2959 |
| Source note | uspto-grants-1996_11 |