Benzoic acid, 2-iodo-, methyl ester → HCID 23370220, compound

HRID 1901111Notes

Reaction equation

HRID 1901111 reaction equation
C([Sn](CCCC)(CCCC)C1C=CN=CC=1)CCC.I[C:21]1[CH:30]=[CH:29][CH:28]=[CH:27][C:22]=1[C:23]([O:25][CH3:26])=[O:24].C([O:38][C:39]1[CH:44]=[C:43]([F:45])[CH:42]=[C:41](Br)[CH:40]=1)C1C=CC=CC=1.CCCCCC.CCOC(C)=O>C1(O)C=CC=CC=1>[F:45][C:43]1[CH:44]=[C:39]([OH:38])[CH:40]=[C:41]([C:21]2[CH:30]=[CH:29][CH:28]=[CH:27][C:22]=2[C:23]([O:25][CH3:26])=[O:24])[CH:42]=1

Participants

6

Reactant 4

HCID 69132Benzoic acid, 2-iodo-, methyl esterHCID 27373184-(Tri-n-butylstannyl)pyridineHCID 112545161-(Benzyloxy)-3-bromo-5-fluorobenzeneHCID 21226206Ethyl acetate hexane

Product 1

HCID 23370220HCID 23370220, compound

Reagents, catalysts & solvents 1

HCID 996PhenolSolvent

Procedure

Following the procedures described in Phenol 1, Steps 2 and 3, but substituting O-(3,4-dimethoxy)benzyl-3-fluoro-5-trimethylstannylphenol for 4-tributylstannylpyridine and methyl 2-iodobenzoate for O-benzyl-3-bromo-5-fluorophenol, the title compound was obtained as an oil after chromatography (silica gel; hexane/EtOAc 95:5-85:15)).

Sources & evidence

ORD record
ord-db92b4f802b248d7bc88550a379b9a5a
Source dataset
uspto-grants-1996_11
Patent number
US05576338

Reaction notes

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