HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 3-Fluoro-5-phenylthiophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | S-(2-Trimethylsilylethyl)-3-fluoro-5-phenylthiophenol | HCID 57070644 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Fluoro-5-phenylthiophenol | HCID 23370217 | — |
Reaction Steps
To S-(2-trimethylsilylethyl)-3-fluoro-5-phenylthiophenol (2.4 g) in DMF (50 mL) was added Bu4NF (16 mL of a 1M THF solution). After 90 min., EtOAc was added and this solution was washed with 1N HCl, H2O and brine. Concentration and chromatography (silica gel; hexane/EtOAc (9:1)) provided the title compound as a liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576338 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-fde2686be1c44a5f80c8583791c536f1 |
| Source note | uspto-grants-1996_11 |