HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → 2-Hydroxymethyl-6-phenylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 2-(tert-Butyldiphenylsiloxy)methyl-6-phenylpyridine | HCID 23370189 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Hydroxymethyl-6-phenylpyridine | HCID 10726186 | — |
Reaction Steps
To a solution of 2-(tert-butyldiphenylsiloxy)methyl-6-phenylpyridine (1.2 g) in THF (20 mL) was added Bu4NF (3.3 mL of a 1M solution in THF). After 1 h, NH4OAc buffer was added and the mixture extracted with EtOAc. The organics were dried (MgSO4), concentrated and chromatographed (silica gel; hexane/EtOAc acetate (3:2)) to provide the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576338 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-484000312709410baee010375debdbdf |
| Source note | uspto-grants-1996_11 |