反应详情

To a solution of methyl 5-phenylnicotinate (640 mg) in THF (20 mL) at 0° C. was added LiAlH4 (3 mL of a 1M solution). After 1 h, H2O (0.12 mL), 15% sodium hydroxide (0.12 mL) and H2O (0.36 mL) were added successively. The mixture was filtered, washing with EtOAc. The filtrate was concentrated and chromatographed (silica gel; EtOAc/hexane (4:1-5:1)) to provide the title compound as a solid.

1. filtrationThe mixture was filtered
2. washwashing with EtOAc
3. concentrationThe filtrate was concentrated
4. customchromatographed (silica gel; EtOAc/hexane (4:1-5:1))