反应详情

温度

165 °C

To 50 g (0.33 mol) of 3-acetoxytoluene from Step 1 was added AlCl3 (60 g, 0.45 mol) and the resulting mixture was heated at 165° C. for 20 min., then cooled to 0° C. and HCl 1N was carefully added followed by Et2O. The aqueous phase was extracted 5× with Et2O and the combined organic phase was washed with brine, dried over MgSO4 and evaporated. The residue was distilled under vacuum to give the title compound.

1. temperaturecooled to 0° C.
2. extractionThe aqueous phase was extracted 5× with Et2O
3. washthe combined organic phase was washed with brine
4. dry with materialdried over MgSO4
5. customevaporated
6. distillationThe residue was distilled under vacuum