HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → ethyl (S)-alpha-(t-butyldimethylsilyloxy)-alpha-phenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | ethyl mandelate, (S)- | HCID 6951557 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | ethyl (S)-alpha-(t-butyldimethylsilyloxy)-alpha-phenylacetate | HCID 10968419 | — |
Reaction Steps
Following a procedure similar to that described in Preparation 23, but using 23.8 g of ethyl (S)-(+)-mandelate, 26.6 g of imidazole, 400 ml of dimethylformamide, 30.1 g of t-butyldimethylsilyl chloride and 100 ml of dimethylformamide, the title compound was obtained as a liquid, boiling at 125.5°/3.0 mmHg (400 Pa).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576340 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-7b974635fbb149f2a2a52005bddb2e1e |
| Source note | uspto-grants-1996_11 |