Potassium Hydroxide → HCID 86750011, compound

HRID 1901236Notes

Reaction equation

HRID 1901236 reaction equation
[F:1][C:2]([F:22])([N:6]1[C:11]([F:13])([F:12])[C:10]([F:15])([F:14])[C:9]([F:17])([F:16])[C:8]([F:19])([F:18])[C:7]1([F:21])[F:20])[C:3]([OH:5])=[O:4].[OH-].[K+:24]>O>[F:22][C:2]([F:1])([N:6]1[C:7]([F:21])([F:20])[C:8]([F:18])([F:19])[C:9]([F:16])([F:17])[C:10]([F:14])([F:15])[C:11]1([F:12])[F:13])[C:3]([O-:5])=[O:4].[K+:24]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 10915339HCID 10915339, compound

Product 1

HCID 86750011HCID 86750011, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Distilled water was placed in a three-neck flask equipped with a reflux condenser and a dropping funnel and a crude product of the electrolytic fluorination of methyl piperidinoacetate was added through the dropping funnel while the three-neck flask was kept cooled. The resultant hydrolyzate was extracted with ether from the reaction mixture, dried with anhydrous sodium sulfate, and then distilled under a vacuum in the presence of a small amount of concentrated sulfuric acid to obtain perfluoropiperidinoacetic acid (bp: 120° C./121 mmHg). This perfluoropiperidinoacetic acid was suspended in distilled water. The suspension was kept agitated by the use of a magnetic stirrer and an aqueous potassium hydroxide solution was added to the agitated suspension until pH 10. The resultant reaction mixture was deprived of water and low-boiling fractions by the use of an evaporator and then dried for one day with a vacuum pump to obtain white solid potassium perfluoropiperidino-acetate.

Workup

  1. customThe resultant reaction mixture
  2. customwas deprived of water and low-boiling fractions by the use of an evaporator
  3. customdried for one day with a vacuum pump

Sources & evidence

ORD record
ord-d87c178d879d49d49cac4b96817a3191
Source dataset
uspto-grants-1996_11
Patent number
US05576431

Reaction notes

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