Potassium Hydroxide → HCID 86750011, compound

Participants

Reaction Steps

Distilled water was placed in a three-neck flask equipped with a reflux condenser and a dropping funnel and a crude product of the electrolytic fluorination of methyl piperidinoacetate was added through the dropping funnel while the three-neck flask was kept cooled. The resultant hydrolyzate was extracted with ether from the reaction mixture, dried with anhydrous sodium sulfate, and then distilled under a vacuum in the presence of a small amount of concentrated sulfuric acid to obtain perfluoropiperidinoacetic acid (bp: 120° C./121 mmHg). This perfluoropiperidinoacetic acid was suspended in distilled water. The suspension was kept agitated by the use of a magnetic stirrer and an aqueous potassium hydroxide solution was added to the agitated suspension until pH 10. The resultant reaction mixture was deprived of water and low-boiling fractions by the use of an evaporator and then dried for one day with a vacuum pump to obtain white solid potassium perfluoropiperidino-acetate.

Provenance & Evidence