3-Hydroxypyridine → HCID 22854932, compound

HRID 1901433Notes

Reaction equation

HRID 1901433 reaction equation
[OH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[CH3:8][O:9][C:10](=[O:27])[C@H:11]1[CH2:15][C@@H:14](O)[CH2:13][N:12]1[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18].COC(=O)[C@H]1C[C@H](OC2C=CC3C(=CC=CC=3)C=2)CN1C(OCC1C=CC=CC=1)=O>>[CH3:8][O:9][C:10](=[O:27])[C@H:11]1[CH2:15][C@H:14]([O:1][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=2)[CH2:13][N:12]1[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18]

Participants

4

Reactant 3

HCID 79713-HydroxypyridineHCID 6884101-Benzyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylateHCID 22854931HCID 22854931, compound

Product 1

HCID 22854932HCID 22854932, compound

Procedure

The title compound was prepared from 3-hydroxy pyridine and N-Cbz-cis-4-hydroxy-D-proline methyl ester by substantially following the procedure used in the preparation of N-Cbz-trans-4-(2-naphthyloxy)-D-proline methyl ester, Example 6, Steps A and B.

Sources & evidence

ORD record
ord-6b6435fb73f148ebb0c03b8ca3422d1b
Source dataset
uspto-grants-1996_11
Patent number
US05578574

Reaction notes

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