反应详情

In a flask is placed 5,8-dimethyl-4-methoxy-6-nitroquinoline (1.16 g, 5.0 mmol) with stannous chloride dihydrate (5.64 g, 25 mmol) and ethanol (50 mL). The mixture is refluxed for 1 hour, diluted with water (100 mL) and concentrated ammonium hydroxide (30 mL), and extracted with chloroform (2×200 mL). The organic portion is dried over potassium carbonate, filtered and the solvents removed by rotary evaporation, yielding 4-amino-5,8-dimethyl-4-methoxyquinoline.

1. customIn a flask is placed
2. temperatureThe mixture is refluxed for 1 hour
3. extractionextracted with chloroform (2×200 mL)
4. dry with materialThe organic portion is dried over potassium carbonate
5. filtrationfiltered
6. customthe solvents removed by rotary evaporation