Isoamyl Nitrite → HCID 73192825, compound

HRID 1901477Notes

Reaction equation

HRID 1901477 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([CH:9]([C:15]#[N:16])C(OCC)=O)[CH2:2]2.[Na].C([O:23][N:24]=O)CC(C)C>C(O)C>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([C:9](=[N:24][OH:23])[C:15]#[N:16])[CH2:2]2

Participants

5

Reactant 3

HCID 8053Isoamyl NitriteHCID 5360545SodiumHCID 15379686HCID 15379686, compound

Product 1

HCID 73192825HCID 73192825, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl (1-azabicyclo[2.2.2]octan-3-yl)cyanoacetate (10 g, 45 mmol) was added to a solution of sodium (1.04 g, 45 mmol) in absolute ethanol (60 ml). The mixture was stirred for 15 min. at room temperature and isoamylnitrite (7.9 ml, 60 mmol) was added. The reaction mixture was stirred for 18 h at 60° C. Evaporation of the reaction mixture gave crude title compound, which was used without further purification.

Workup

  1. stirringThe reaction mixture was stirred for 18 h at 60° C
  2. customEvaporation of the reaction mixture

Sources & evidence

ORD record
ord-08557610ca65408ea9f44d30a3548684
Source dataset
uspto-grants-1996_11
Patent number
US05578602

Reaction notes

Loading…